This article was last reviewed in February of 2018 and is based on research available at that time. We will attempt to update this page as new evidence and best practice becomes available.
Many people may be aware of the recent resurgence in talk surrounding whole blood transfusions on the battlefield. There is quite a bit of stigma surrounding blood product administration. This article is meant to empower medics in talking with their battalion PAs and Surgeons about Fresh Whole Blood (FWB). Hopefully, we can challenge the dogmatic approach to resuscitation in favor of some good evidence-based medicine.
Step 1: Read the Literature
Decisions in medicine are made, in large part, based on the evidence presented in scientific medical literature. The thing that will best help you discuss whole blood with your medical director is to know it yourself. Take the time to find and read the articles linked below each answer.
Frequently Asked Questions
Q: Why are we having this conversation?
A: In 2014 the JTS Committee on Tactical Combat Casualty Care, recommended whole blood as the resuscitation fluid of choice. FWB is the fluid of choice for battlefield resuscitation of traumatically hypovolemic patients. FWB has been used by the U.S. Military since WWI and more recently in Combat Support Hospitals (CSH), Forward Surgical Teams (FST), Forward Resuscitative Surgery Systems (FRSS), and even aircraft carriers at sea. Also called Walking Blood Banks, these organizations have been drawing and transfusing whole blood into wounded patients since the beginning of the war. Recent medical research has provided evidence of the safety, efficacy, and benefits of collecting and transfusing whole blood in the field for Remote Damage Control Resuscitation (RDCR). Any delay in massive transfusion is associated with prolonged time to achieve hemostasis and an increase in mortality. Regardless of whether you are using component blood products or whole blood, the odds of mortality increase approximately 5% with each minute blood is delayed. Training for the use of FWB improves overall survival and reduces disability.
- Fresh Whole Blood Transfusion: Military and Civilian Implications (Crit Care Nurse, 2016)
- Warm Fresh Whole Blood Is Independently Associated With Improved Survival for Patients With Combat-Related Traumatic Injuries (J Trauma, 2009)
- Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients. (Transfusion, 2011)
- Every minute counts: Time to delivery of initial massive transfusion cooler and its impact on mortality. (J Trauma Acute Care Surg, 2017)
Q: What are the indications for FWB transfusion?
A: FWB is the preferred fluid for resuscitation of suspected hemorrhagic shock in the traumatically injured patient. FWB is ideal for anemic, acidotic, hypothermic, coagulopathic patients with life-threatening traumatic injuries in hemorrhagic shock.
TCCC Guidelines for Combat Medics
Assess for hemorrhagic shock:
- If not in shock PO fluids are permissible if casualty is conscious and can swallow
- If in shock resuscitate with:
- Whole blood (preferred)
- Plasma, RBCs, and/or platelets (1:1:1 ratio)
- Plasma and RBCs (1:1 ratio)
- Reconstituted/liquid/thawed plasma alone or RBCs alone
- Lactated Ringers
- Resuscitate with above fluids until a palpable radial pulse, improved mental status or systolic BP of 80-90 mmHg is present. Discontinue fluids when one or more end points are achieved
- Reassess casualty frequently to check for recurrence of shock after each unit or 500ml bolus. If shock recurs, verify all hemorrhage is under control and repeat fluid resuscitation as above
- If TBI suspected, resuscitate as necessary to restore and maintain a normal radial pulse
You should consider the condition of your patient and your tactical situation. If you expect any delay in evacuation or your patient has extensive injuries and has already lost a significant amount of blood, the sooner you initiate the transfusion, the more likely they will survive.
- TCCC Guidelines for Medical Personnel August 2017
- Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital (World J Surg, 2008)
Q: What makes FWB so great?
A: Whole blood has all of the red blood cells, clotting factors, and platelets that the patient needs to be resuscitated all in one bag, all transfusing at the same time. When a patient has lost enough blood to be in shock, what they need most is blood back in their body. There is some controversy surrounding the degradation of stored blood components. These concerns do not apply to fresh whole blood.
- Fresh versus old blood: are there differences and do they matter? (Hematology, 2013)
- Whole blood: the future of traumatic hemorrhagic shock resuscitation (Shock, 2014)
- Whole blood for hemostatic resuscitation of major bleeding. (Transfusion, 2016)
Q: What is wrong with how we have been doing things?
A: For decades the standard was to infuse large quantities of saline into the hypovolemic trauma patient. Within the first few years of the current conflicts, we realized that we were causing preventable death and disability associated with diluting the oxygen-carrying and clotting capabilities of the body (called dilutional anemia). Furthermore, over-resuscitating a patient with crystalloids has been shown to contribute to pulmonary dysfunction at the 3-day mark.
The common standard for massive transfusions in large hospitals is a 1:1:1 ratio of packed red blood cells (pRBC), fresh frozen plasma (FFP), and platelets. Smaller facilities like Forward Surgical Teams (FST) and medical evacuation platforms like Pedro (U.S. Air Force PJs) and DUSTOFF (Conventional Army MEDEVAC), and MERT (U.K. Army Medical Emergency Response Team) tend to only have pRBC and FFP, but not platelets, due to the logistical burden. Currently, platelets have a five-day shelf life, must be stored at room temperature and oscillated. Studies show that FWB has similar benefits to the standard 1:1:1 transfusion protocol. In austere environments where standard blood products are unavailable, FWB is a viable alternative.
- Fresh whole blood use by forward surgical teams in Afghanistan is associated with improved survival compared to component therapy without platelets. (Transfusion, 2013)
- Lethal injuries and time to death in a level I trauma center. (J Am Coll Surg, 1998)
- Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. (Crit Care Med, 2000)
- Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (Transfusion, 2011)
Q: Why not just use Freeze Dried Plasma (FDP)?
A: Freeze-dried plasma is much better than saline for fluid resuscitation because it doesn’t dilute clotting factors. Although it is not FDA-approved yet, FDP is being used by U.S. Special Operations Forces overseas with great results. Our French counterparts have been using it since the 90’s. However, FDP doesn’t replace the oxygen-carrying red blood cells in FWB. There have been no controlled trials studying this, but data from WWII indicates increased survival once the U.S. switched from bottles of plasma to group O whole blood. The switch was credited by the Surgeons General of the Army and Navy as being the greatest lifesaver of World War II.
“Plasma gives more time to get whole blood into the patient. ” HK Beecher, WWII
Q: Isn’t blood transfusion a risky procedure?
A: If done properly, FWB transfusions have a very good risk to benefit ratio. All medical procedures have an inherent level of risk if done carelessly or incorrectly. The main thing that most folks are concerned with is transfusion reactions. There is a 1:80,000 chance of transfusion reaction with matched blood types, and a 1:120,000 chance of a reaction with matched plasma. The reactions, if seen, are commonly mild and range from pain at the injection site, to rash and fever. In any case, there does not appear to be any increased risk of morbidity or mortality from infusing incompatible plasma. These are not commonly noticeable outside of a well-controlled transfusion center. Even in major trauma centers here in the U.S., most physicians aren’t concerned with flushing and pruritus while resuscitating the trauma patient.
Less likely but more severe reactions include acute hemolytic anemia (AHA), transfusion-related acute lung injury (TRALI), and transfusion-related circulatory overload (TACO). Medics should know how to identify and treat these reactions, but should not delay resuscitation because it might cause a reaction.
The worst kind of transfusion reaction is known as Transfusion Related Graft vs. Host Disease (tGVHD). It is exceedingly rare, there is no way to test for it, and if your patient gets it there is no treatment. There has been only one documented case of tGVHD in more than 10,000 military FWB transfusions.
- Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital (Crit Care Med, 2007)
- Incompatible type A plasma transfusion in patients requiring massive transfusion protocol: Outcomes of an Eastern Association for the Surgery of Trauma multicenter study (J Trauma Acute Care Surg, 2017)
Q: What about Rh factor reactions?
A: A mismatch in the Rhesus (Rh) D antigen doesn’t cause an immediate hemolytic reaction after the first exposure and is nearly irrelevant in the emergency prehospital setting. According to the American Red Cross, 10-20% of the U.S. population does not have the Rh D antigen on the surface of their red blood cells, also known as Rh “negative”. After exposure to Rh “positive” blood, around 20-26% will develop a sensitivity within four weeks. However, only 3-4% will develop a strong immune response to a future administration. While it is common practice to give women of childbearing age Rh-negative blood, if it isn’t available, Rh-positive whole blood should be transfused as it’s still preferred over colloid or crystalloid infusion.
- Safety of uncrossmatched type-O red cells for resuscitation from hemorrhagic shock. (J Trauma, 2005)
- Rhesus Negative Woman Transfused With Rhesus Positive Blood: Subsequent Normal Pregnancy Without Anti D production (Ghana Med J, 2015)
- Emergency transfusion of patients with unknown blood type with blood group O Rhesus D positive red blood cell concentrates: a prospective, single-centre, observational study. (Lancet, 2017)
Q: What about blood-borne diseases?
A: FWB is meant to be taken from a U.S. service member and given to a battlefield casualty. This allows the donor to be screened for common transmissible diseases. Additionally, the risk of infectious disease transmission with FWB transfusion can be minimized by rapid screening tests for HIV, hepatitis B (HBV), hepatitis C (HCV), malaria, and syphilis (RPR) before transfusion. During the wars in Iraq and Afghanistan, there have been over 10,000 fresh whole blood transfusions. Of those, there has been one case of hepatitis C and one case of tGVHD which resulted in the death of the recipient.
Q: Isn’t “A to A, and O for everyone else” reckless?
A: There is an extremely low risk of lethal transfusion reaction from FWB. The wildly successful Ranger O Low Titer (ROLO) Whole Blood Program uses low titer group O whole blood for every casualty on the battlefield.
However, in cases of small teams or low numbers of group O donors, the mnemonic “A to A and O to everyone else” is a safe option. During WWII, almost all transfusions were group O whole blood, regardless of titer or the patient’s blood group. The very nature of the conditions in which FWB transfusion takes place doesn’t lend itself to a well-controlled trial. About 80% of the population is either type-A or type-O. The remaining 20% is divided between types-B and -AB. While the chances of a reaction are higher in this 20%, the rate is still low and the effects tend to be mild. If faced with the choice between possible mild transfusion reaction and likely or certain death from hemorrhagic shock, the choice is clear. Trying to find an exact whole blood match for group B and AB patients may cause an unacceptable delay in care.
- Tactical Damage Control Resuscitation (Mil Med, 2015)
Q: Does taking blood from a healthy Soldier put them at risk during combat?
A: No. There is no significant decrease in either physical or in shooting performance after donating 1 unit (450mL) of whole blood. Studies show buddy transfusion is feasible for healthy well-trained soldiers and does not decrease donor combat performance under ideal circumstances.
- Donor performance of combat readiness skills of special forces soldiers are maintained immediately after whole blood donation. (Transfusion, 2013)
Q: Can regular medics perform blood administration?
A: Yes. Administration of Blood Products is already a 68W MOS task (081-835-3054) in STP 8-68W13-SM-TG (CAC Required). Minimal additional training is needed to safely perform field FWB transfusions. Conventional units across the military are currently implementing the 75th Ranger Regiment’s ROLO program. Stay tuned to Next Generation Combat Medic for more information about starting a ROLO program at your unit! Some civilian EMS agencies have even started using Cold Stored Type-O Low Titre Whole Blood for fluid resuscitation of patients in hypovolemic shock.
Q: Can trained non-medical personnel perform whole blood collection?
A: Yes. Non-medical personnel can start whole blood collection provided they are well trained and are able to practice frequently. The 75th Ranger Regiment trains Advanced Ranger First Responders to collect FWB from pre-designated donors.
Q: Can I just use Dog Tags to select donors?
A: You probably shouldn’t. Military ID tags do have the blood type on them but are subject to an error rate. They can be used to identify potential donors but confirmatory testing with a rapid blood typing system, such as an Eldon Card should be used. A much better option is to screen and identify donors before deployment. Using rapid blood typing cards or military issued ID tags to determine blood types should be your last resort.
Q: Is it possible to overdose on FWB?
A: You should fluid resuscitate until you see a positive change in mental status or can feel a radial pulse. If you have the time and equipment, you should resuscitate to a mean arterial pressure (MAP) of 65. Over-resuscitation with any fluid can cause poor outcomes.
Specifically for the administration of blood products is the issue of hypocalcemia. Blood is collected in bags containing sodium citrate. Sodium citrate prevents the blood’s clotting cascade from activating in the bag prior to administration. Each unit of blood contains approximately 3 grams citrate, which binds with calcium in the body to deactivate the natural clotting mechanisms. The healthy adult liver will metabolize 3 grams of citrate about every 5 minutes. However, transfusion above this rate, with an impaired liver, or into an already acidotic patient can lead to citrate toxicity and hypocalcemia. This hasn’t been shown to have an effect on clotting, but it can cause some mild to moderate side effects such as muscle tremors or spasms (tetany), hypotension, or allergic reaction (urticaria). This can all be treated or avoided with the administration of calcium gluconate after the first unit of FWB.
- Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis (Int J Clin Exp Med, 2015)
- Citrate Toxicity During Massive Blood Transfusion (Transfusion Med Rev, 1988)
Q: What if I don’t use the blood I collected?
A: FWB can be stored at room temperature for up to 8 hours and then refrigerated after that for up to 21 days. Generally speaking though, if you don’t use it in 24 hours, it’s probably not an emergency and you can dispose of it. If you hand your patient off to another level of medical provider, unless they have access to type-specific blood products, you should give them the blood you’ve collected. MEDEVAC personnel have already been transfusing blood products in the field for years and should be very familiar with how to proceed.
Additional Resources for Gettin’ Smart
Fresh Whole Blood Transfusion “FAQ’s” in Prolonged Field Care (LTC Andrew Cap, 2014)
Medscape – Rh Incompatibility (Salem, Lo, 2017)
Ranger Whole Blood Program wins an Army’s Greatest Innovation Award (Maj. Tony Mayne, 2017)
(PODCAST) PJ Medcast #54: The Ranger Blood Program (2016)
(PODCAST) Blood Bank Guy Episode 40: “Wholly Whole Blood!” with Mark Yazer (2017)